Increasingly, beta blockers are being utilized to treat patients with
aggressive disorders secondary to brain lesions. To secure further data
about the potential efficacy of beta blockers for this condition, a rat
model was employed in which aggression was enhanced by 6- hydroxydopamine.
Following lesioning of the brain, aggression in the rats increased from an
average baseline of 10.9 +/- 2.1 to 42.7 +/- 2.0 fights per testing period.
Thereafter, either pharmacologically inert, artificial CSF or nadolol was
introduced through transcerebral, intraventricular perfusion with a
significant reduction in aggression in the nadolol-treated animals when
compared with those receiving artificial CSF.Abstract Teaser