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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 1, No. 3

Article | August 01, 1989

The clinical utility of pharmacological agents that act at serotonin receptors

The Journal of Neuropsychiatry and Clinical Neurosciences 1989;1:253-262.

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Abstract

The past decade has seen important advances in the clinical utility of serotonergic agents. The putative novel anxiolytic effects of 5-HT1A partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-HT) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-HT3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-HT receptor agents. The increasing ability to modulate serotonergic neurotransmission through distinct 5-HT receptor subtypes should greatly facilitate the analysis of 5-HT in both normal and abnormal human brain function.

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