This study attempted to identify microscopic correlates to the
structural abnormalities reported in the corpus callosum of schizophrenic
patients. Sections of the genu, body, and splenium of the corpus callosum
were taken from formalin-fixed brains of deceased patients with
schizophrenia and nonschizophrenic control subjects. Photomicrographs of
stained tissue were projected, and nerve fibers were counted. There were no
significant differences (p greater than 0.4) in axonal counts between
schizophrenic and control patients for any of the sites sampled. Our
results suggest that morphometric abnormalities of the corpus callosum of
schizophrenic patients, if present, are not the consequence of a primary
process within this structure.Abstract Teaser