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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 1, No. 4

Article | November 01, 1989

Brain iron in progressive supranuclear palsy: clinical, magnetic resonance imaging, and neuropathological findings

The Journal of Neuropsychiatry and Clinical Neurosciences 1989;1:400-404.

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Abstract

A patient with progressive supranuclear palsy demonstrated a region- specific decrease in T2 signal during high-field-strength brain magnetic resonance imaging. At autopsy the T2-signal hypointensity was found to correspond topographically to increased deposition of ferric iron. The potential clinical, radiologic, and pathophysiologic implications of these findings are discussed.

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