The effects of metoclopramide on ketamine-induced linguopharyngeal
events exemplified by tongue retrusions, protrusions, and swallowing acts
were tested in ketamine-anesthetized rats mounted on a stereotaxic frame
with the tip of the tongue tied to a force displacement transducer to
monitor retrusion and protrusion and a pressure transducer inserted into
the mouth at the level of the soft palate to monitor swallowing.
Metoclopramide at doses ranging from 0.5 to 50 mg/kg im failed to decrease
protrusions, retrusions, or swallowing. It rather increased all three
events for up to 2.5 hours. The significance of these findings is
discussed.Abstract Teaser