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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 2, No. 4

Article | November 01, 1990

Expression of a neural cell adhesion molecule serum fragment is depressed in autism

The Journal of Neuropsychiatry and Clinical Neurosciences 1990;2:413-417.

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Abstract

The level of a neural cell adhesion molecule (NCAM) serum fragment in autism was determined by using an antiserum prepared with immunoaffinity purified mouse NCAM. Autistic patients (N = 16) had statistically significantly decreased serum NCAM levels compared with age-matched controls (p less than 0.0005). This observation could not be attributed to a medication-induced effect. Depressed serum NCAM levels in autism are distinct from schizophrenia, in which serum NCAM levels are elevated.

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