A subgroup of subjects (4 of 12) with childhood soft signs and
adolescent anxiety-withdrawal disorders were followed up into adulthood and
assessed for soft signs and psychiatric diagnoses. These subjects continued
to have soft-sign abnormalities and most had adult anxiety or affective
disorders, including obsessive-compulsive disorder (OCD). In contrast,
control subjects with childhood soft signs but no adolescent anxiety
disorders had fewer soft signs at follow-up and no discrete adult anxiety
or affective disorders, but they did have obsessive- compulsive symptoms
that did not meet criteria for OCD.Abstract Teaser