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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 4, No. 4

Article | November 01, 1992

Reduction of CSF monoamine metabolites in poststroke depression: a preliminary report

The Journal of Neuropsychiatry and Clinical Neurosciences 1992;4:440-442.

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Abstract

Monoamine metabolites were measured in the cerebrospinal fluid (CSF) of depressed and nondepressed patients with acute stroke lesions and in nondepressed patients without stroke lesions. Depressed stroke patients had a significantly lower concentration of CSF 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite) than the other two groups. These findings suggest that poststroke depression may be mediated by serotonergic mechanisms.

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