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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 4, No. 4

Article | November 01, 1992

Prolonged postictal encephalopathy in two patients with clozapine- induced seizures

The Journal of Neuropsychiatry and Clinical Neurosciences 1992;4:454-457.

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Abstract

Two patients with prolonged postictal encephalopathy lasting 63 and 72 hours, respectively, following seizures with clozapine are reported. Clozapine alters the EEG in a majority of patients treated, with seizure frequency as high as 5-10% in doses above 600 mg/d. Prolonged postictal encephalopathy following a clozapine-induced seizure has not been previously reported but may be an important side effect of this medication. Pharmacologic and clinical issues are discussed.

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