In the last two decades, many biological functions of iron have been
identified, in particular its role in many enzymatic processes, its effect
on dopamine D2 receptor function, its interaction with other
neurotransmitters (gamma-aminobutyric acid, serotonin, opiate- peptides),
and its catalytic role in the nonenzymatic mechanisms for oxidation,
hydroxylation, and peroxidation reactions. The role of iron in Parkinson's
disease, Alzheimer's disease, brain injury due to exogenous causes,
neuroleptic-induced movement disorders, schizophrenia, and other
neuropsychiatric disorders is currently being explored. This study
summarizes current understanding of the anatomy and physiology of brain
iron with special reference to these disorders.Abstract Teaser