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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 6, No. 2

Article | May 01, 1994

Clinical correlates of body weight changes in schizophrenia

The Journal of Neuropsychiatry and Clinical Neurosciences 1994;6:187-188.

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Abstract

Body weight was examined in chronic schizophrenic patients. Underweight medicated patients had normal ventricular brain ratios (VBRs) on CT. Overweight patients had both normal and abnormal VBRs. Weight decreased during neuroleptic withdrawal; caloric intake and weight increased when neuroleptics were reinstituted. Weight gain on neuroleptics correlated with symptom improvement independent of VBR or gender. Weight changes and psychosis in schizophrenia may be mediated by similar neurochemical systems.

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