Many patients with schizophrenia show clinical signs of frontal lobe
dysfunction, including blunted affect, difficulty with problem solving, and
impoverished thinking. The authors present cytoarchitectural,
neuropsychological, and functional neuroanatomical evidence of frontal
abnormalities from recent studies of frontal dysfunction in schizophrenia.
It is suggested that the failure of intracortical connectivity of the
prefrontal cortex accounts for both cognitive and psychotic manifestations
of this illness.Abstract Teaser