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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 7, No. 2

Article | May 01, 1995

The dementia of Gerstmann-Straussler-Scheinker syndrome: clinical variability demonstrated by two case reports

The Journal of Neuropsychiatry and Clinical Neurosciences 1995;7:239-242.

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Abstract

Two cases of Gerstmann-Straussler-Scheinker syndrome (GSS) are discussed in detail. These cases illustrate the variable clinical course and mostly cortical features of GSS-associated dementia. Given the availability of genetic tests that can now diagnose GSS, clinicians should consider these tests in cases where patients with dementia have extensive family histories or if the clinical course is atypical for Alzheimer's or vascular dementia.

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