Eighty normal adults were studied with MRI to investigate the
relationship between regional morphology of the corpus callosum and
characteristics such as age, gender, education, and cranial size. The
variability coefficient was 20% in total callosal area and from 19% to 40%
in regional callosal area. Increasing age and smaller cranial area were
both associated with smaller total and regional callosal areas; there were
no effects of gender and education. The relative effects of age and cranial
size varied across regions and were most prominent for anterior
subdivisions. However, age and cranial size together explained less than
half the variance in regional callosal size. Further study is needed to
identify additional correlates of regional callosal anatomy.Abstract Teaser