Advanced Search

The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 7, No. 4

Article | November 01, 1995

The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease

The Journal of Neuropsychiatry and Clinical Neurosciences 1995;7:476-484.

Article

text A A A

PDF of the full text article.

Abstract

Cognitive and noncognitive psychiatric symptoms were systematically evaluated in 21 patients with Alzheimer's disease by using the Neurobehavioral Rating Scale. Regional cerebral metabolic activity was measured in each patient by [18F]fluorodeoxyglucose PET. Significant correlations emerged between global cortical metabolic activity and the Agitation/Disinhibition factor score, Cognition factor score, and total score. Relationships between noncognitive symptoms and metabolic activity were regionally specific, with significant correlations between Agitation/Disinhibition factor score and metabolism in the frontal and temporal lobes, between Psychosis factor score and metabolism in the frontal lobe, and between Anxiety/Depression factor score and metabolism in the parietal lobe. These results suggest that psychiatric symptoms are fundamental expressions of the cortical dysfunction of Alzheimer's disease.

Figures in this Article

Your Session has timed out. Please sign back in to continue.

Username

Password

Sign in via Athens (What is this?)

Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.

Forgot Password?

Not a subscriber?

Subscribe Now/Learn More

Purchase Online access to this article for 24 hours

PsychiatryOnline subscription options offer access to the DSM-IV-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.

Submit a Comments

Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of JBJS editorial staff.

* = Required Field

Comment Author(s)*(if multiple authors, separate names by comma)

Example: John Doe

Affiliation & Institution*

Comment Title*

Comment*

Cancel

Topics

Product Recommendation

CME Activity