Cavum septi pellucidi (CSP) is a midline developmental anomaly shown to
have increased incidence in patients with schizophrenia. The etiology of
CSP may involve dysgenesis of the temporal lobes. This study evaluated the
pattern of brain changes in three groups: 1) normal control subjects, 2)
schizophrenic subjects without large CSP, and 3) schizophrenic subjects
with large CSP. Patients without large CSP had decreased total brain,
frontal, and temporal lobe volumes; patients with the anomaly had more
pronounced right > left asymmetry and volume decrement limited to the
left temporal lobe. These findings indicate that patients with
schizophrenia and large CSP may show a different pattern of disturbed brain
morphology than patients without this abnormality.Abstract Teaser