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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 8, No. 2

Article | May 01, 1996

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

The Journal of Neuropsychiatry and Clinical Neurosciences 1996;8:223-226.

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Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

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