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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 8, No. 3

Article | August 01, 1996

Apo-E genotype and verbal deficits in Alzheimer's disease

The Journal of Neuropsychiatry and Clinical Neurosciences 1996;8:335-337.

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Abstract

Apo-E genotype was not significantly related to cognitive performance in 157 Alzheimer's disease patients. However, patients homozygous for the epsilon 4 allele appeared most impaired on global cognition but least impaired on language measures. Further study with larger samples may reveal that Apo-E genotype accounts for some of the variability in cognitive deficits observed in Alzheimer's disease.

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