Data from 30 elderly inpatients with major depression were analyzed to
explore the relationship between subcortical hyperintensities (SH) on MRI
and activities of daily living (ADLs). A comparison of subjects based on a
median split of the severity of SH revealed that subjects with greater SH
performed worse on both instrumental and physical ADLs. A hierarchical
multiple regression revealed that age, depression severity,
neuropsychological test performance, and SH variables accounted for a total
of 53% of the variance in ADL functioning. Severity of SH accounted for an
additional 18% of the variance over and above the other three variables.
Results suggest that severity of subcortical disease measured by MRI
improves prediction of functional impairment in elderly individuals.Abstract Teaser