In an administration of the Computerized Neuropsychological Test Battery
(CNTB), stable schizophrenic outpatients (n = 26) showed significant
impairment (P < 0.05) relative to normal control subjects (n = 28) in
overall function and measures of verbal learning. Except on tests of motor
speed, the performance profile of schizophrenic patients was similar to
that of elderly normal control subjects (n = 33). This profile of deficits
is consistent with findings of other investigators in similar patient
populations. In addition to displaying sensitivity to the mild impairments
found in outpatients, the CNTB showed high test- retest reliability (r =
0.76, P < 0.0001). It should be useful for evaluating cognitive
impairment in clinical trials of prospective treatments.Abstract Teaser