Current knowledge leaves open the question of central nervous system (CNS) dysfunction in vaginismus. In a recent study of CNS control mechanisms underlying pelvic-floor functioning in patients with vaginismus, they found hyperexcitable cortical somatosensory evoked-potential recovery cycle and bulbocavernos in vaginismus.3 The features of sexual dysfunction were suggested to be different among localization-related epilepsy and primary-generalized epilepsy; women with localization-related epilepsy may present with more sexual anxiety, dyspareunia, vaginismus, arousal insufficiency, and sexual dissatisfaction, whereas women with primary, generalized epilepsy experienced more anorgasmia and sexual dissatisfaction.4 Some studies have documented improvement in sexual function after temporal lobectomy. The postoperative sexual changes were proposed in the majority of the studies in temporal lobe epilepsy. Right-temporal resections were found to be more likely to affect sexual functioning than left-sided resections.5 Although the abovementioned studies emphasized the relationship between epilepsy and sexual dysfunction, we could not find any report about postoperative vaginismus-onset in woman with epilepsy. We considered that the postoperative worsening sexual function, that is, having vaginismus symptoms in the current case, might be due to left temporal-lobe resection in the presence of an unchanged drug treatment regimen. However, multiple factors, such as additional brain injury, psychosocial factors, and cognitive and temperamental attributes might be kept in mind in assessing sexual problems after epilepsy surgery. Thus, the relationship between vaginismus and epilepsy surgery deserves to be researched in further studies.