The most common cause of dysgeusia is the damage of taste cells induced by zinc deficiency,1 in which total dysgeusia occurs. In the present case, dysgeusia did not disappear with the normalization of serum zinc concentration. Anhedonia, loss of interest in and withdrawal from all regular and pleasurable activities including experiences of sensory pleasures (e.g. taste or smell), is a cardinal feature of major depressive disorder. Recently, Dichter et al reported that anhedonia observed in patients with major depressive disorder is not associated with sensory responses to sweet tastes measured by the sweet taste test.4 Thus, the impairment of cognitive function to evaluate pleasurable stimuli might occur in the major depressive disorder. On the other hand, the effect of SSRIs on taste perception could occur at the level of taste receptor cells.5 In healthy volunteers, paroxetine, another SSRI, increases both sweet and bitter sensitivity by reducing taste threshold by 27 and 53%, respectively.5 In the present case, sertraline might improve taste disturbances by enhancing the serotonergic neurotransmission resulting in the reduction of taste threshold. Dysgeusia is one of neglected symptoms of depression.2 Whatever the underlying mechanism, sertraline appears to be an effective treatment for patients suffered from dysgeusia.