Are Selective Serotonin Reuptake Inhibitors Associated With Greater Apathy in Parkinson’s Disease?
- Laura B. Zahodne,
Ph.D. , - Oscar Bernal-Pacheco,
M.D. , - Dawn Bowers,
Ph.D. , - Herbert Ward,
M.D. , - Genko Oyama,
M.D. , - Natlada Limotai,
M.D. , - Frances Velez-Lago,
M.D. , - Ramon L. Rodriguez,
M.D. , - Irene Malaty,
M.D. , - Nikolaus R. McFarland,
M.D., Ph.D. , and - Michael S. Okun,
M.D.
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
From the Dept of Neurology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (OB-P, DB, GO, NL, FV-L, RLR, IM, NRM, MSO); the Dept. of Clinical and Health Psychology, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (LBZ, DB); the Dept. of Psychiatry, Center for Movement Disorders and Neuro-restoration University of Florida, Gainesville, FL (HW); and the Dept. of Neurosurgery, Center for Movement Disorders and Neuro-restoration, University of Florida, Gainesville, FL (MSO).
Abstract
Apathy is a common neuropsychiatric feature of Parkinson’s disease (PD), but little is known of relationships between apathy and specific medications in PD. Following a retrospective database and chart review of 181 Parkinson’s patients, relationships between Apathy Scale scores and use of psychotropic and antiparkinsonian medications were examined with multiple regression. Controlling for age, sex, education, and depression, the use of selective serotonin reuptake inhibitors (SSRIs), but not other antidepressants, was associated with greater apathy. Use of monoamine oxidase B inhibitors was associated with less apathy. Longitudinal studies are needed to evaluate a potential SSRI-induced apathy syndrome in PD.
