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Combination Therapy of Zonisamide With Aripiprazole on ECT- and Benzodiazepine-Resistant Periodic Catatonia
Masanori Nakagawa; Satoshi Yamamura; Eishi Motomura; Takashi Shiroyama; Hisashi Tanii; Motohiro Okada
The Journal of Neuropsychiatry and Clinical Neurosciences 2012;24:10009-10009. 10.1176/appi.neuropsych.11080191
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Department of Psychiatry, Graduate School of Medicine, Mie University
Brain Science and Animal Model Center (BSAM), Mie University
Mie, Japan

Extract

To the Editor: Two types of clinical forms of catatonia are established, systematic and periodic catatonia. Periodic catatonia features catatonic stupor alternating with excitement, waxing and waning for years. Systematic catatonia is responsive to benzodiazepine and electroconvulsive therapy (ECT); however, periodic catatonia is poorly responsive to these two major treatments. Here, we report a case of ECT- and benzodiazepine-resistant periodic catatonia in a patient with schizophrenia and the successful treatment of refractory catatonic symptoms with combination therapy of a novel antiepileptic antiparkinsonian agent, zonisamide, and a dopamine D2 receptor partial agonist, aripiprazole.

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References

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Okada  M;  Kaneko  S:  Different mechanisms underlying the antiepileptic and antiparkinsonian effects of zonisamide, in  Epilepsy . Edited by Foyaca-Sibat  H.  Rijeka,  INTECH,  2011in press.
 
Murata  M;  Hasegawa  K;  Kanazawa  I; Japan Zonisamide on PD Study Group:  Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study.  Neurology   2007; 68:45–50
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