There is much work evidencing the enhanced peripheral expression of the chemokine CCL3 (MIP-1α) and also its chemokine receptor, CCR5, from AD patients. However, no study showing its expression in peripheral cells from FTD patients has been reported. Therefore, our aim was to investigate the chemokine and its receptor expression in the peripheral cells of FTD patients and compare with AD patients’ cells. We found a decreased expression of CCL3 in the monocytes CD14+ from FTD patients (5.86 [2.88]), as compared with AD patients (14.4 [21.10]; p=0.04; Figure 1). In a similar way, we observed a decreased CCR5 expression in CD4+ T-lymphocytes from FTD patients (0.57 [0.66]), as compared with AD patients (2.40 [1.30]; p=0.02) (Figure 1). Sample size for the AD group was 48 (16 men/32 women) and, for FTD, 12 (5 men/7 women). The mean age of AD patients was 81.09 (6.60) and, for FTD, was 72.0 (12.5); mean (SD) MMSE score in AD was 13.35 (3.75) and in FTD was 16.8 (6.9).