A 74-year-old, right-handed woman was referred to our clinic for evaluation of memory complaints. Her past medical history was unremarkable and negative for dementia. On examination, she had brisk tendon reflexes, Babinski sign bilaterally, and primitive reflexes. Her MMSE score was 18. Neuropsychological evaluation revealed poor episodic, visual and verbal memory, as well as learning deficits compatible with AD. A brain MRI showed generalized atrophy. She was discharged with the diagnosis of AD, and donepezil was prescribed. Two days after her dismissal, her daughter called us, saying fearfully that her mother’s head and body were turned in one side. The patient had suffered acute Pisa syndrome a few hours after donepezil treatment was initiation. The drug was discontinued. On follow-up, 8 days later, her head position had turned back to normal.