To the Editor: Creutzfeldt-Jacob disease is a prion disease which is characterized by progressive neurodegeneration that is always fatal. The onset is usually in the fifth or sixth decade. The onset of illness is fifth or sixth decade in case of sporadic CJD but cases are reported at earlier ages. New-variant CJD (nvCJD) accounts for < 1% of all CJD and it usually affects adults. It results when the patients are exposed to contaminated products and transplants. Early prodromal stage is characterized by neurasthenic symptom lasting weeks or months. Sometimes, objective findings may be lacking and confused with functional psychiatric disorder. Course is usually rapidly deteriorating and majority of patients die within two years of onset of illness. Nonspecific clinical findings, rare presentation and need of advanced neuro-radiological, serological and autopsy make the diagnosis difficult.