On admission, she received haloperidol 10 mg intramuscularly (i.m.), diazepam 10 mg i.m., and biperiden 10 mg i.m. Her treatment during her hospitalization (which lasted for 57 days) is shown in detail in Figure 1, except for benzodiazepines, long-acting risperidone i.m., valproate, and thyrohormone. The fluctuation of the clinical picture is also shown in the same figure. On Day 7, she manifested hypersalivation and peripheral muscular rigidity. There was a disagreement among therapists concerning the etiology of the rigidity, because of the lack of cogwheel and other extrapyramidal signs and symptoms (EPS). However, she was treated with biperiden. The disappearance of rigidity does not seem to temporally relate to the anticholinergic treatment. Her treatment included high dosages of olanzapine and haloperidol later on, but the symptoms persisted. On Day 18, she had a 38.5°C fever, treated with paracetamol and antibiotics. Clinical and laboratory examinations were normal. In order to control her disorganized behavior, high dosages of olanzapine were used, on a step-by-step basis, during Days 17–23, and the patient seemed to respond at dosages close to 100 mg daily. However, the core symptoms persisted. On Day 21, she manifested severe hypersalivation, hoarseness of voice, but no peripheral muscular rigidity. On Day 25, her treatment changed, and the new one was based on haloperidol 30 mg daily and valproate 1,500 mg daily.