The first patient, a 58-year-old married woman with anxiety, depressed mood, and somatic complaints, including involuntary rhythmic movements of the head and neck, was diagnosed with major depressive disorder. After prescribing 10 mg/day escitalopram, 1 month later, depressive symptoms were mildly improved, but intermittent movement symptoms remained. To reduce movement symptoms and augment antidepressant effects, aripiprazole was prescribed at 5 mg/day, then titrated to 10 mg/day. Three weeks later, involuntary movement symptoms and depressive symptoms were alleviated. Five months later, she stopped her medicine at her discretion and movement symptoms recurred. On 7.5 mg/day of aripiprazole, the patient was stabilized, with no signs of depressive symptoms or involuntary movement symptoms.