To the Editor: Clozapine is rarely associated with venous thromboembolic phenomena. The reason for the association between clozapine and thromboembolism is largely unknown. Here we report a rare case of pulmonary thromboembolism (PTE) in a middle-aged man who was admitted to the cardiac intensive care unit with a history of sudden-onset breathlessness and tightness in the chest. He had been on treatment for resistant schizophrenia with clozapine for the last 8 months. A thorough history did not reveal any possible risk factors for PTE.