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COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder
Raşit Tükel, M.D.; Hakan Gürvit, M.D.; Nalan Öztürk, M.D.; Berna Özata, M.D.; Banu Aslantaş Ertekin, M.D.; Erhan Ertekin, M.D.; Bengi Baran, M.A.; Şükriye Akça Kalem, M.A.; Deniz Büyükgök, M.A.; Güher Saruhan Direskeneli, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:214-221. doi:10.1176/appi.neuropsych.12040103
View Author and Article Information

The authors of this study have no financial conflicts of interest. This work was supported by the Research Fund of the Istanbul University (BYPS-12-5/131206).

From the Istanbul Faculty of Medicine, Department of Psychiatry (RT, NO, BO, BAE, EE, DB), Dept. of Neurology, Behavioral Neurology, and Movement Disorders Unit (HG, BB, SAK), Dept. of Physiology (GSD), Istanbul University, Istanbul, Turkey.

Send correspondence to Dr. Raşit Tükel; e-mail: rtukel@gmail.com

Copyright © 2013 American Psychiatric Association

Received April 24, 2012; Revised September 16, 2012; Accepted September 24, 2012.

Abstract

This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.

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TABLE 1.Primers Used in Val158Met COMT Polymorphism Analysis by Tetra-Primer ARMS-PCR
Table Footer Note

The 3′-end of the allele-specific primers is underlined. Underlined lowercase bases indicate the introduced mismatches; COMT: catechol-O-methyltransferase.

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TABLE 2.Genotype and Allele Distributions in OCD and Control Groups
Table Footer Note

OCD: obsessive-compulsive disorder; COMT: catechol-O-methyltransferase.

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TABLE 3.Demographic and Clinical Characteristics in OCD Patients With Val158Val Genotype and Met Carriers (OCD patients with Val158Met or Met158Met genotypes)
Table Footer Note

OCD: obsessive-compulsive disorder; Y-BOCS: Yale-Brown Obsessive-Compulsive Scale.

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TABLE 4.Descriptive Statistics for Executive Function Measures for the Val/Val and Met-Carrier OCD and Control Groups
Table Footer Note

Means in a row with different subscript letters indicate significant differences (p <0.05) according to the Bonferroni post-hoc test. OCD: obsessive-compulsive disorder.

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