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Letters   |    
Donepezil-Induced Confusional State in a Patient With Autopsy-Proven Behavioral-Variant Frontotemporal Dementia
David B. Arciniegas, M.D.; C. Alan Anderson, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E25-E26. doi:10.1176/appi.neuropsych.12060158
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Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX; and Behavioral Neurology Section
Dept. of Neurology University of Colorado School of Medicine Aurora, CO

Correspondence: david.arciniegas@bcm.edu

Copyright © 2013 American Psychiatric Association

Extract

To the Editor: Behavioral-variant frontotemporal dementia (bvFTD) produces complex combinations of challenging behaviors, including disinhibition, apathy, loss of empathy, perseverative/compulsive behaviors, hyperorality, and executive dysfunction.1 Since there are no United States Food and Drug Administration-approved treatments for bvFTD, symptom-targeted off-label pharmacotherapy is commonplace. These treatments are often modeled on those provided to persons with other neurodegenerative dementias, including Alzheimer’s disease (AD).

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References

Rascovsky  K;  Hodges  JR;  Knopman  D  et al:  Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.  Brain 2011; 134:2456–2477
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Lampl  Y;  Sadeh  M;  Lorberboym  M:  Efficacy of acetylcholinesterase inhibitors in frontotemporal dementia.  Ann Pharmacother 2004; 38:1967–1968
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Mendez  MF;  Shapira  JS;  McMurtray  A  et al:  Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia.  Am J Geriatr Psychiatry 2007; 15:84–87
[CrossRef] | [PubMed]
 
Kerchner  GA;  Tartaglia  MC;  Boxer  A:  Abhorring the vacuum: use of Alzheimer’s disease medications in frontotemporal dementia.  Expert Rev Neurother 2011; 11:709–717
[CrossRef] | [PubMed]
 
Beglinger  LJ;  Gaydos  BL;  Kareken  DA  et al:  Neuropsychological test performance in healthy volunteers before and after donepezil administration.  J Psychopharmacol 2004; 18:102–108
[CrossRef] | [PubMed]
 
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