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Donepezil-Induced Confusional State in a Patient With Autopsy-Proven Behavioral-Variant Frontotemporal Dementia
David B. Arciniegas, M.D.; C. Alan Anderson, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E25-E26. doi:10.1176/appi.neuropsych.12060158
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Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX; and Behavioral Neurology Section
Dept. of Neurology University of Colorado School of Medicine Aurora, CO

Correspondence: david.arciniegas@bcm.edu

Copyright © 2013 American Psychiatric Association


To the Editor: Behavioral-variant frontotemporal dementia (bvFTD) produces complex combinations of challenging behaviors, including disinhibition, apathy, loss of empathy, perseverative/compulsive behaviors, hyperorality, and executive dysfunction.1 Since there are no United States Food and Drug Administration-approved treatments for bvFTD, symptom-targeted off-label pharmacotherapy is commonplace. These treatments are often modeled on those provided to persons with other neurodegenerative dementias, including Alzheimer’s disease (AD).

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