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Successful Treatment With Blonanserin for Drug-Induced Hyperprolactinemia in Chronic Schizophrenia Patients: A Six-Month Follow-Up of Two Cases
Shinsuke Kito, M.D., Ph.D.; Takashi Hasegawa, M.D., Ph.D.; Toru Nakajima, M.D., Ph.D.; Yoshihiko Koga, M.D., Ph.D.; Shintaro Hibi, M.D.; Yukiko Tobe, M.D.; Masahiko Mochida, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E29-E30. doi:10.1176/appi.neuropsych.12060161
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Dept. of Neuropsychiatry Kyorin University School of Medicine Tokyo, Japan
Tokyokaido Hospital Tokyo, Japan
Tama Hospital Tokyo, Japan

Correspondence: Shinsuke Kito, M.D., Ph.D.; e-mail: kito@ks.kyorin-u.ac.jp

Copyright © 2013 American Psychiatric Association


To the Editor: Some antipsychotics cause elevations in serum prolactin (PRL) levels, which can lead to galactorrhea, infertility, menstrual disorders, sexual dysfunction, and reduction in bone mineral density,1 although recent atypical antipsychotics do so less often than conventional ones. We present two cases of chronic schizophrenia with risperidone-induced hyperprolactinemia, of whom one, especially, had sexual dysfunction. Their elevated PRL levels were normalized after switching to blonanserin.

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TABLE 1.Clinical Characteristics and Changes in Serum PRL Levels in Two Schizophrenia Patients With a Six-Month Follow-Up
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BW indicates body weight (kg); PRL, prolactin (ng/ml); BPRS, Brief Psychiatric Rating Scale score.



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