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Letters   |    
Experience With Intramuscular Zuclopenthixol and Medroxyprogesterone Acetate in the Treatment of Agitation and Aggression in Huntington’s Disease
Soham Rej, M.D.; René Desautels, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E33-E34. doi:10.1176/appi.neuropsych.12070164
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Soham Rej is funded by the FRSQ Master’s Training Award for Health Professionals. No financial support was received specifically for this paper and there are no potential conflicts of interest to report.

This paper is a case report (letter to the editor) for publication and has not been previously presented or published.

Preparation for this manuscript was carried out at the Department of Psychiatry, Douglas Mental Health University Institute, and McGill University, Montréal, Canada.

Dept. of Psychiatry McGill University Montréal, Canada
Division of Geriatric Psychiatry Douglas Mental Health University Institute Montréal, Canada
Dept. of Psychiatry McGill University Montréal, Canada

e-mail: Dr. Rej; soham.rej@mail.mcgill.ca

Copyright © 2013 American Psychiatric Association

Extract

To the Editor: We present the case of a 58-year-old man with Huntington’s disease (HD) with agitation and aggression successfully treated with intramuscular zuclopenthixol and medroxyprogesterone. Medroxyprogesterone, however, caused abdominal bloating. Intramuscular zuclopenthixol was helpful in our patient and may be useful in other HD patients who refuse oral medications.

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References

Bolea-Alamanac  BM;  Davies  SJ;  Christmas  DM  et al:  Cyproterone to treat aggressivity in dementia: a clinical case and systematic review.  J Psychopharmacol 2011; 25:141–145
[CrossRef] | [PubMed]
 
Johnston  TG:  Risperidone long-acting injection and Huntington’s disease: case series with significant psychiatric and behavioural symptoms.  Int Clin Psychopharmacol 2011; 26:114–119
[CrossRef] | [PubMed]
 
Kales  HC;  Kim  HM;  Zivin  K  et al:  Risk of mortality among individual antipsychotics in patients with dementia.  Am J Psychiatry 2012; 169:71–79
[PubMed]
 
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