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Letters   |    
Clozapine-Induced Recurrent Pulmonary Thromboembolism
Ravindra Neelakanthappa Munoli, M.B.B.S.; Samir Kumar Praharaj, M.B.B.S., M.D., D.P.M.; Sripathy M. Bhat, M.B.B.S., D.P.M., M.D., M.N.A.M.S.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E50-E51. doi:10.1176/appi.neuropsych.12070186
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Sources of support: None

Dept. of Psychiatry Kasturba Medical College Manipal, Karnataka, India
Dept. of Psychiatry Kasturba Medical College Manipal, Karnataka, India
Dept. of Psychiatry Kasturba Medical College Manipal, Karnataka, India

Correspondence: Dr. Praharaj; e-mail: samirpsyche@yahoo.co.in

Copyright © 2013 American Psychiatric Association

Extract

To the Editor: Clozapine is an atypical antipsychotic, effective in the treatment of resistant schizophrenia.1 Its widespread use has been limited by its adverse drug profile, which includes agranulocytosis, sedation, weight gain, diabetes mellitus, seizures, and myocarditis.24 Pulmonary thromboembolism is a rarely reported adverse effect with clozapine therapy.5,6 In a study of the 67,072 patients registered in the Clozaril National Registry between 1991 and 1993, the absolute risk of death from pulmonary embolism was increased by a factor of 5.2 among current clozapine users, as compared with past users of clozapine.5 We report on a patient with chronic schizophrenia on clozapine 50 mg/day, who developed recurrent episodes of pulmonary thromboembolism, which did not recur after discontinuation and symptomatic treatment.

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