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Letters   |    
Low-Dose Quetiapine for the Treatment of Delusional Disorder in a Patient With Von Hippel-Lindau Disease
Om Prakash, M.D.; Amit Garg, M.D.; Pallavi Sinha, M.B.B.S.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E54-E54. doi:10.1176/appi.neuropsych.12080192
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There was no funding support and no conflicts of interest.

Institute of Human Behaviour & Allied Sciences (IHBAS) Delhi, INDIA

Correspondence: Dr. Prakash; e-mail: drjhirwalop@yahoo.co.in; drjhirwalop@hotmail.com

Copyright © 2013 American Psychiatric Association

Extract

To the Editor: Von Hippel-Lindau (VHL) disease1 is an autosomal, dominantly-inherited disorder caused by germline mutations in the VHL tumor-suppressor gene (TSG) that predispose to the development of retinal and central nervous system hemangioblastomas, clear-cell renal carcinoma, and pheochromocytoma. Quetiapine, a dibenzothiazepine derivative antipsychotic has been used in the treatment of schizophrenia and related disorders.2,3 We report on a case of delusional disorder along with VHL disease and its treatment with low doses of quetiapine without any considerable side effects. No such report has been described before.

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References

Maher  ER;  Neumann  HP;  Richard  S:  von Hippel-Lindau disease: a clinical and scientific review.  Eur J Hum Genet 2011; 19:617–623
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Riedel  M;  Müller  N;  Strassnig  M  et al:  Quetiapine in the treatment of schizophrenia and related disorders.  Neuropsychiatr Dis Treat 2007; 3:219–235
[CrossRef] | [PubMed]
 
Chae  BJ;  Kang  BJ:  Quetiapine for hypersexuality and delusional jealousy after stroke.  J Clin Psychopharmacol 2006; 26:331–332
[CrossRef] | [PubMed]
 
Price Trevor  RP:  Neuropsychiatric aspects of brain tumors, in  Kaplan & Sadock’s Comprehensive Textbook of Psychiatry , 9th Edition, vol. 2. Edited by Sadock  BJ;  Sadock  VA;  Ruiz  P.  Baltimore, MD,  Lippincott Williams & Wilkins, 2009, pp 435–451
 
Jain  V;  Bishnoi  A;  Meena  K  et al:  Metachronous occurrence of multifocal phaeochromocytoma.  Indian J Pediatr 2011; 78:620–622
[CrossRef] | [PubMed]
 
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