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Clinical and Research Reports   |    
Disulfiram-Induced Combined Irreversible Anterior Ischemic Optic Neuropathy and Reversible Peripheral Neuropathy: A Prospective Case Report and Review of the Literature
Ranganath R. Kulkarni, M.D.; A. V. Pradeep, M.S.; Bhavya K. Bairy, M.B.B.S.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:339-342. doi:10.1176/appi.neuropsych.12120410
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From the Dept. of Psychiatry (RRK, BKB), Dept. of Ophthalmology (AVP), SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.

Send correspondence to Dr. Kulkarni; e-mail: dranant007@rediffmail.com

Copyright © 2013 by the American Psychiatric Association

Received December 28, 2012; Accepted February 22, 2013.


Disulfiram is an alcohol-deterring agent with few rare serious adverse effects, usually dose-related, reversible, and more frequent with comorbid alcohol and nicotine dependence. We report a prospective follow-up of such a case with reversible peripheral neuropathy and irreversible optic neuropathy.

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FIGURE 1. Fundus Showing [A] Right Optic Disc Temporal Pallor and [B] Left Optic Disc Pallor With Edema

FIGURE 2. Fundus Fluorescein Angiography (FFA) Showing [A] Right Normal Perfusion and [B] Left Blurred Optic Disc Margins With Sectoral Optic Head Hypoperfusion

FIGURE 3. Fundus Fluorescein Angiography (FFA) Showing Left Optic Head Leak in the Late Phase

FIGURE 4. Fundus Showing Left Optic Disc Atrophy After 6 Months of Follow-Up


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