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Letters   |    
Chemotherapy-Induced Pseudobulbar Affect: A Novel Case
Wan Yi Min, M.B. B.Ch. BAO (Ireland), M.R.C.Psych. (UK); C.B. Khare, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E11-E13. doi:10.1176/appi.neuropsych.12090211
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Dept. of Psychological Medicine, National University Hospital (NUH), Singapore

Correspondence: Dr. Wan Yi Min; e-mail: Yi_Min_WAN@juronghealth.com.sg

Copyright © 2013 by the American Psychiatric Association

Extract

To the Editor: Pseudobulbar affect (PBA) is a disorder of emotional expression and regulation characterized by uncontrollable outbursts of laughing, crying, or both, that are unrelated to, or out of proportion to, the subjective emotions felt by the patient. It could cause distress, embarrassment, curtailment of social activities, and reduction in quality of life.

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References

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Wilson  SAK:  Some problems in neurology, II: pathological laughing and crying.  J Neurol Psychopathol 1924; 4:299–333
 
Work  SS;  Colamonico  JA;  Bradley  WG  et al:  Pseudobulbar affect: an under-recognized and under-treated neurological disorder.  Adv Ther 2011; 28:586–601
 
Miller  A;  Pratt  H;  Schiffer  RB:  Pseudobulbar affect: the spectrum of clinical presentations, etiologies, and treatments.  Exp Rev Neurother 2011; 11:1077–1088
 
Haiman  G;  Pratt  H;  Miller  A:  Brain responses to verbal stimuli among multiple sclerosis patients with pseudobulbar affect.  J Neurol Sci 2008; 271:137–147
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Arciniegas  D;  Lauterbach  EC;  Anderson  KE  et al: The differential diagnosis of pseudobulbar affect (PBA): distinguishing PBA among disorders of mood and affect.  CNS Spectr 2005; 10(suppl):1–16
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Brooks  BR;  Thisted  RA;  Appel  SH  et al:  Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.  Neurology 2004; 63:1364–1370
 
Klein  M;  Musacchio  JM.  High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.  J Pharmacol Exp Ther . 1989; 251(1):207–215
 
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