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A Novel Case Report: Acute Manic Psychotic Episode After Treatment With Niacin
Tsafrir Loebl, M.D.; Sergey Raskin, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E14-E14. doi:10.1176/appi.neuropsych.12090212
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Kfar Shaul Psychiatric Hospital
The Jerusalem Mental Health Center
Affiliated with Hadassah Medical School, The Hebrew University
Jerusalem 91060, Israel

Correspondence: Tsafrir Loebl, M.D.; e-mail: l.tsafrir@gmail.com

Copyright © 2013 by the American Psychiatric Association


To the Editor: Awareness of the role of food supplements for various medical problems has been increasing in recent years. Niacin (Vitamin B3) has been proven to raise HDL and lower triglyceride levels.1 Niacin is a precursor to several neurotransmitters in the brain, which may have an impact on mood. Niacin sensitivity is inversely correlated with severity of symptoms, and flush deficits were significantly associated with depressed mood and anxiety.2 Except for hot flushes, it is considered to be a safe medication.

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Ito  MK:  The metabolic syndrome: pathophysiology, clinical relevance, and use of niacin.  Ann Pharmacother 2004; 38:277–285
[CrossRef] | [PubMed]
Smesny  S;  Baur  K;  Rudolph  N  et al:  Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder.  J Affect Disord 2010; 124:335–340
[CrossRef] | [PubMed]
website: http://www.ehealthme.com/ds/niacin/mania; accessed Aug 11, 2012
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