0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Letters   |    
Brain Resilience and Obsessive-Compulsive Disorder: Defining the Neuroanatomical Pathways of Vulnerability
João Ricardo Mendes de Oliveira; Matheus Fernandes de Oliveira
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E19-E21. doi:10.1176/appi.neuropsych.12090220
View Author and Article Information

Neuropsychiatric Department and Keizo Asami Laboratory
Federal University of Pernambuco (UFPE)
Recife, Pernambuco, Brazil

Department of Neurosurgery
Hospital do Servidor Público Estadual de São Paulo
São Paulo, Brazil

Correspondence: Dr. JRM Oliveira; e-mail: joao.ricardo@ufpe.br

Copyright © 2013 by the American Psychiatric Association

Extract

To the Editor: Obsessive-compulsive disorder (OCD) is highly prevalent, affecting up to 2% of the world population, and presenting an important genetic component, which has been consistently suggested by several genetic−epidemiological studies, and especially inferred from comparative analysis of twin studies.1,2 Different studies estimate heritability rates as varying between 27% and 47% in adults with OCD and 45%−65% in pediatric forms.1,2 These findings suggest that environmental factors or gene factors dependent on environment interactions should be accounted for a variability ranging between 35% and 73%.1,2

Figures in this Article

First Page Preview

View Large
/>
First page PDF preview
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

Jonnal  AH;  Gardner  CO;  Prescott  CA  et al:  Obsessive and compulsive symptoms in a general population sample of female twins.  Am J Med Genet 2000; 96:791–796
[CrossRef] | [PubMed]
 
van Grootheest  DS;  Cath  DC;  Beekman  AT  et al:  Twin studies on obsessive-compulsive disorder: a review.  Twin Res Hum Genet 2005; 8:450–458
[CrossRef] | [PubMed]
 
Braber  AD;  Ent  DV;  Boomsma  DI  et al:  White-matter differences in monozygotic twins discordant or concordant for obsessive-compulsive symptoms: a combined diffusion tensor imaging/voxel-based morphometry study.  Biol Psychiatry 2011; [E-pub ahead of print]
 
Oliveira  JRM;  Oliveira  MF;  Kuhni  R  et al: Neuroimaging genetics studies in basal ganglia calcification as a model to understand brain resilience, in The Israel Society for Neuroscience 19th Annual Meeting, 2011, J Mol Neurosci 2011
 
de Oliveira  MF;  Pinto  FC;  Nishikuni  K  et al:  Revisiting hydrocephalus as a model to study brain resilience.  Front Hum Neurosci 2011; 5:181
[PubMed]
 
Price  CJ;  Friston  KJ:  Degeneracy and cognitive anatomy.  Trends Cogn Sci 2002; 6:416–421
[CrossRef] | [PubMed]
 
Oliveira  JRM;  Lima Filho  JL;  Zatz  M:  Identical twins with idiopathic basal ganglia calcification (“Fahr’s disease”) presenting with a remarkably similar pattern of neuroimaging findings.  Parkinsonism Relat Disord 2009; 15:396–397
[CrossRef] | [PubMed]
 
Noppeney  U;  Friston  KJ;  Price  CJ:  Degenerate neuronal systems sustaining cognitive functions.  J Anat 2004; 205:433–442
[CrossRef] | [PubMed]
 
Rende  R;  Plomin  R:  Families at risk for psychopathology: who becomes affected and why? Dev Psychopathol 1993; 5:529–540
[CrossRef]
 
Eidelberg  D:  Metabolic brain networks in neurodegenerative disorders: a functional imaging approach.  Trends Neurosci 2009; 32:548–557
[CrossRef] | [PubMed]
 
Kempton  MJ;  Haldane  M;  Jogia  J  et al:  Dissociable brain structural changes associated with predisposition, resilience, and disease expression in bipolar disorder.  J Neurosci 2009; 29:10863–10868
[CrossRef] | [PubMed]
 
Bullmore  E;  Sporns  O:  Complex brain networks: graph theoretical analysis of structural and functional systems.  Nat Rev Neurosci 2009; 10:186–198
[CrossRef] | [PubMed]
 
Bassett  DS;  Bullmore  E:  Small-world brain networks.  Neuroscientist 2006; 12:512–523
[CrossRef] | [PubMed]
 
Geschwind  DH;  Loginov  M;  Stern  JM:  Identification of a locus on chromosome 14q for idiopathic basal ganglia calcification (Fahr disease).  Am J Hum Genet 1999; 65:764–772
[CrossRef] | [PubMed]
 
de Oliveira  JR;  de Lemos  RR;  de Oliveira  MF:  Updating genetic studies in familial idiopathic basal ganglia calcification.  South Med J 2009; 102:989
[CrossRef] | [PubMed]
 
Oliveira  MF;  Oliveira  JR:  A comorbid case of familial idiopathic basal ganglia calcification (“Fahr’s disease”) associated with post-polio syndrome.  J Neuropsychiatry Clin Neurosci 2012; 24:E14–E15
[CrossRef] | [PubMed]
 
Oliveira  JR;  Steinberg  SS:  Far from rare: revisiting the relevance of idiopathic basal ganglia calcifications.  Neurol Sci 2010; 31:679
[CrossRef] | [PubMed]
 
Jang  JH;  Kim  JH;  Jung  WH  et al:  Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder.  Neurosci Lett 2010; 474:158–162
[CrossRef] | [PubMed]
 
Zhang  T;  Wang  J;  Yang  Y  et al:  Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder.  J Psychiatry Neurosci 2011; 36:23–31
[CrossRef] | [PubMed]
 
Stopczynski  RE;  Poloskey  SL;  Haber  SN:  Cell proliferation in the striatum during postnatal development: preferential distribution in subregions of the ventral striatum.  Brain Struct Funct 2008; 213:119–127
[CrossRef] | [PubMed]
 
den Braber  A;  Ent  DV;  Blokland  GA  et al:  An fMRI study in monozygotic twins discordant for obsessive-compulsive symptoms.  Biol Psychol 2008; 79:91–102
[CrossRef] | [PubMed]
 
References Container
+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 9.  >
APA Practice Guidelines > Chapter 11.  >
APA Practice Guidelines > Chapter 11.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 51.  >
The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th Edition > Chapter 23.  >
Topic Collections
Psychiatric News
APA Guidelines
PubMed Articles