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Letters   |    
Brain Resilience and Obsessive-Compulsive Disorder: Defining the Neuroanatomical Pathways of Vulnerability
João Ricardo Mendes de Oliveira; Matheus Fernandes de Oliveira
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E19-E21. doi:10.1176/appi.neuropsych.12090220
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Neuropsychiatric Department and Keizo Asami Laboratory
Federal University of Pernambuco (UFPE)
Recife, Pernambuco, Brazil

Department of Neurosurgery
Hospital do Servidor Público Estadual de São Paulo
São Paulo, Brazil

Correspondence: Dr. JRM Oliveira; e-mail: joao.ricardo@ufpe.br

Copyright © 2013 by the American Psychiatric Association


To the Editor: Obsessive-compulsive disorder (OCD) is highly prevalent, affecting up to 2% of the world population, and presenting an important genetic component, which has been consistently suggested by several genetic−epidemiological studies, and especially inferred from comparative analysis of twin studies.1,2 Different studies estimate heritability rates as varying between 27% and 47% in adults with OCD and 45%−65% in pediatric forms.1,2 These findings suggest that environmental factors or gene factors dependent on environment interactions should be accounted for a variability ranging between 35% and 73%.1,2

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