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Letters   |    
A Case of Primary Progressive Aphasia Associated With Psychosis
Nahla Mahgoub, M.D.; Michelle Errante-Nordlinger, L.S.W.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E26-E26. doi:10.1176/appi.neuropsych.12100236
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Dept. of Psychiatry
Weill Medical College of Cornell University, Westchester Division
White Plains, NY

Weill Medical College of Cornell University, Westchester Division
White Plains, NY

Copyright © 2013 by the American Psychiatric Association

Extract

To the Editor: Primary progressive aphasia (PPA) is a neurodegenerative disease that was first described as a distinct syndrome by Mesulam, in 1982.1 It affects the language network located in the left hemisphere of the brain and includes the perisylvian parts of the inferior frontal and temporoparietal regions.2 It is a disorder of expressive language, with intact comprehension. It is associated with gradual impairment of word-processing, object-naming, poor grammatical structure, and phonemic paraphasias.13 As the illness progresses, the neurodegenerative process extends to adjacent structures and affects other cognitive and behavioral domains.3 Literature has explored the relationship of PPA with neuropsychiatric illnesses such as dementia and depression; however, psychosis in PPA has not been investigated.

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References

Mesulam  MM:  Slowly progressive aphasia without generalized dementia.  Ann Neurol 1982; 11:592–598
[CrossRef] | [PubMed]
 
Mesulam  MM:  Primary progressive aphasia: a language-based dementia.  N Engl J Med 2003; 349:1535–1542
[CrossRef] | [PubMed]
 
Mesulam  MM:  Primary progressive aphasia.  Ann Neurol 2001; 49:425–432
[CrossRef] | [PubMed]
 
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