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Modafinil for the Treatment of Antipsychotic-Induced Excessive Daytime Sedation: Does It Exacerbate Tics?
Gayatri Saraf, M.B.B.S.; Biju Viswanath, M.D.; Janardhanan C. Narayanaswamy, M.D.; Bharath Holla, M.B.B.S.; Suresh Bada Math, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E35-E36. doi:10.1176/appi.neuropsych.12100246
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Dept. of Psychiatry
National Institute of Mental Health and Neurosciences
Bangalore, India

Correspondence: Dr. Biju Viswanath; e-mail: bijuv1@gmail.com

Copyright © 2013 by the American Psychiatric Association


To the Editor: Excessive daytime sedation (EDS) is a common and disabling side effect of antipsychotics (AP). We report on a case of a 17-year-old patient with difficult-to-treat symptoms of obsessive-compulsive disorder, chronic tic disorder, and primary derealization syndrome, whose compliance was noted to be poor because of AP-induced EDS. We successfully used modafinil for the treatment of this AP-related EDS, but with initial exacerbation of tics. This report highlights the need for careful dose-titration of modafinil, especially in those with past or family history of tic disorders.

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