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How Heterogeneous Can the Clinical Presentation for Creutzfeldt-Jacob Disease Be?
Silvana Sobreira, M.D.; Isabela A. Mota, M.D.; José Eriton Gomes da Cunha, B.S., M.Sc.; Roberto Mello, M.D., Ph.D.; João Ricardo Oliveira, Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:E44-E45. doi:10.1176/appi.neuropsych.12110264
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The Authors have no conflicts of interest.

Hospital da Restauração, Pernambuco University, Recife, PE, Brazil (SS)
Federal University of Paraíba, Brazil (IAM)
Federal University of Pernambuco, Recife, PE, Brazil (JEGC, RM, JRO)

Correspondence: Dr. João Ricardo Mendes de Oliveira, Federal University of Pernambuco; joao.ricardo@ufpe.br

Copyright © 2013 by the American Psychiatric Association


To the Editor: Creutzfeldt-Jakob disease (CJD) is a heterogeneous clinical condition, usually presenting in a sporadic form (sCJD) and affecting about 0.5–1.5 cases per million inhabitants, showing particularities on pathological and clinical features, according to western blot analysis of Prion scrapie protein (PrPsc).1

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TABLE 1.Summary of Main Characteristics: Four Definite Cases of Creutzfeld-Jakob Disease


Ironside  JW;  Ritchie  DL;  Head  MW: Phenotypic variability in human prion diseases. Neuropathol Appl Neurobiol 2005; 31:565–579; available from http://www.ncbi.nlm.nih.gov/pubmed/16281905
Shekhawat  LS;  Kumar  S;  Ramdurg  SI  et al:  New variant Creutzfeldt-Jacob disease presenting with catatonia: a rare presentation.  J Neuropsychiatry Clin Neurosci 2012; 24:E51–E53
[CrossRef] | [PubMed]
Jardri  R;  DiPaola  C;  Lajugie  C  et al: Depressive disorder with psychotic symptoms as psychiatric presentation of sporadic Creutzfeldt-Jakob disease: a case report.
Martins  VR;  Gomes  HR;  Chimelli  L  et al:  Prion diseases are under compulsory notification in Brazil: surveillance of cases evaluated by biochemical and / or genetic markers from 2005 to 2007.  Dementia Neuropsychologia 2007; 1:347–355
Paterson  RW;  Torres-Chae  CC;  Kuo  AL  et al:  Differential diagnosis of Creutzfeldt-Jakob disease.  Arch Neurol 2012; Sept. (e-pub):1–5
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