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REGULAR ARTICLES   |    
Patterns of Cognitive Performance in Subcortical Ischemic Vascular Disease (SIVD)
Martin Scherr, M.D.; Yvonne Krenn, M.D.; Christian Sorg, M.D.; Andrei Manoliu, M.D.; Eugen Trinka, M.D.; Hans Förstl, M.D.; Wolfgang Staffen, M.D.; Hans Jürgen Bergmann, M.D.; Margarita Kirschner, M.D.; Mark McCoy, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:150-154. doi:10.1176/appi.neuropsych.12050117
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From the Dept. of Neurology, Paracelsus Medizinische Privatuniversität Salzburg; the Dept. of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München; Dept. of Neuroradiology, Klinikum rechts der Isar, Technische Universität München; the Neuroscience Institute, Christian Doppler Klinik, Paracelsus Medical University Salzburg, Austria; the Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria; and the Division of Neuroradiology, Paracelsus Medizinische Privatuniversität Salzburg, Austria.

Send correspondence to Dr. Scherr; e-mail: m.scherr@salk.at

Copyright © 2014 by the American Psychiatric Association

Received May 10, 2012; Revised December 12, 2012; Accepted December 18, 2012.

Abstract

Subcortical ischemic vascular disease (SIVD) is characterized by extensive white-matter lesions and lacunar infarcts in deep gray matter. The aim of this study was to investigate patterns of cognitive impairment in patients with SIVD. In a retrospective analysis, the authors compared the cognitive performance of 58 patients meeting MRI-defined criteria for SIVD (26 women; 47.3%) with age- and gender-matched control subjects. SIVD patients showed impairments in measures of verbal fluency, verbal memory, speed of cognitive processing, and divided attention. There were no significant differences in constructional praxis, figurative memory, verbal recognition memory, or semantic processing.

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TABLE 1.Demographic Characteristics and MRI Findings
Table Footer Note

Values are mean (standard deviation) analyzed with Mann-Whitney U test, unless otherwise indicated.

Table Footer Note

N (%) significance values analyzed by χ2 test.

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TABLE 2.Group Comparison: SIVD Versus Reference Group
Table Footer Note

Values are mean (standard deviation). Significance values analyzed by Mann-Whitney U test.

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