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REGULAR ARTICLES   |    
Neuropsychological Outcomes After Psychosocial Intervention for Depression in Parkinson’s Disease
Roseanne D. Dobkin, Ph.D.; Alexander I. Tröster, Ph.D.; Jade Tiu Rubino, Psy.D.; Lesley A. Allen, Ph.D.; Michael A. Gara, Ph.D.; Margery H. Mark, M.D.; Matthew Menza, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:57-63. doi:10.1176/appi.neuropsych.12120381
View Author and Article Information

This study was funded by 1 K23 NS052155-01A2 awarded to Roseanne D. Dobkin by the National Institute of Neurological Disorders and Stroke (NIH/NINDS). This trial is registered at clinicaltrials.gov: Identifier NCT00464464.

From the Depts. of Psychiatry and Neurology, Robert Wood Johnson Medical School, University of Medicine & Dentistry of New Jersey, and the Barrow Neurological Institute, Arizona (AIT).

Send correspondence to Dr. Dobkin; e-mail: dobkinro@umdnj.edu

Copyright © 2014 by the American Psychiatric Association

Received December 03, 2012; Accepted February 01, 2013.

Abstract

The authors describe neuropsychological outcomes in people with Parkinson’s disease (PD) after their participation in an NIH-sponsored, randomized, controlled trial of cognitive-behavioral treatment for depression. Improvements in mood were associated with modest gains in verbal memory and executive functioning over the 10-week treatment period and accounted for greater variance in neuropsychological outcomes at the end of treatment than other known correlates of cognitive functioning in PD, such as disease severity, age, and education. Baseline working memory and executive skills were also associated with depression improvement over time.

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TABLE 1.Means and Standard Deviations (SD) for Baseline Neuropsychological Measures
Table Footer Note

HVLT–R: Hopkins Verbal Learning Test–Revised; D–KEFS: Delis–Kaplan Executive Function System. All data presented are standardized scores (HVLT–R: mean: 50; SD: 10; all other measures, mean: 10, SD: 3).

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TABLE 2.Stepwise Linear-Regression Models: Depression, Memory, and Executive Skills in Parkinson’s Disease
Table Footer Note

SD: standard deviation; CI: confidence interval; HVLT–R: Hopkins Verbal Learning Test–Revised; UPDRS: Unified Parkinson’s Disease Rating Scale; Inhibition: Delis-Kaplan Executive Function System Color–Word Interference Subtest.

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TABLE 3.Stepwise Linear-Regression Models: Anxiety and Memory in Parkinson’s Disease
Table Footer Note

SD: standard deviation; CI: confidence interval; HVLT–R: Hopkins Verbal Learning Test–Revised; UPDRS: Unified Parkinson’s Disease Rating Scale.

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