No significant difference was noted in the s-serotonin or u-8-OH-dG level between the groups in any menstrual phase. Meanwhile, the SDS and STAI scores were strongly correlated in the late menstrual phase (r=0.687, p=0.009) in the depressive symptom group. The data suggest that PMS is severe and anxiety is marked in depressive symptom groups. The SDS score in the late menstrual phase was correlated with the total u-8-OH-dG (r=0.580, p=0.045) and s-serotonin levels (r=0.596, p=0.031) in the depressive symptom group. The depressive group was sensitive to stress, resulting in possible DNA injury, which may have enhanced the u-8-OH-dG level.2 Mood-regulatory neurotransmitters, mainly serotonin, may have caused depressive symptoms.3 These may have caused the changes in hormone secretion, interacting with serotonin and producing differences in hormonal sensitivity.