A 50-year-old man, suffering from a major drug-resistant depressive episode that had evolved over 2 years in a context of unipolar depression, was referred to our department for rTMS therapy. For this patient, we decided to delivered 1-Hz rTMS sessions (360 pulses per session, 120% motor threshold) 1 week after all psychotropic drugs were stopped. MRI-based neuronavigation was used to localize the cortical site of stimulation (eXimia NBS Navigation System). We first used the “5-cm method” to target the DLPFC, which consists in localizing the motor cortical site that stimulates the abductor pollicis brevis muscle of the contralateral hand, and then measuring 5 cm anteriorly along the scalp surface in order to target the DLPFC.3 However, in our patient, as this method gave a cortical site outside BA 9 (in fact, in BA 8), the coil was moved to 6 cm anterior to the primary motor cortex in order to target BA 9 (figure 1). After the patient had received daily rTMS sessions from monday through friday for 6 weeks and then two rTMS sessions per week for 4 weeks, the Montgomery-Asberg Depression Rating Scale and the Hamilton Rating Scale for Depression scores, initially evaluated at 32/60 and 23/63, dropped to 8/60 and 05/63.