A 22-year-old man diagnosed with hypomania in remission and off medication presented with depressive symptoms characterized by sad mood, anhedonia, anergia, lethargy, decreased appetite, and increased sleep for the last fortnight. There was no history of substance misuse or family history of affective disorder; however, history of alcohol dependence syndrome was positive in the patient's uncle. The patient was diagnosed with DSM-IV-TR bipolar II depression and was prescribed bupropion sustained-release, 150 mg/day, which was increased to 150 mg bid after 3 days. After about 3 weeks, the patient switched to hypomania characterized by euphoria, voluble speech, decreased need for sleep, overactivity, grandiosity, and increased sexual attraction to girls. His symptoms were controlled with lithium 900 mg/day, olanzapine 10 mg/day, and clonazepam 0.5 mg/day, and he achieved euthymia after 4 weeks. All medications except lithium were tapered off gradually, and the patient is in remission now for the last 2 months.